 |
|
| RTECS Number |
DJ3675000 |
| Chemical Name |
Benzo(a)pyrene |
| CAS Registry Number |
50-32-8 |
| Last Updated |
200802 |
| Data Items Cited |
656 |
| Molecular Formula |
C20-H12 |
| Molecular Weight |
252.32 |
| Wiswesser Line Notation |
L D6 B6666 2AB TJ |
| Compound Descriptor |
Tumorigen
Mutagen
Human
Primary Irritant
Reproductive Effector |
- Synonyms/Trade Names
- 3,4-BP
3,4-Benz(a)pyrene
3,4-Benzopirene
3,4-Benzopyrene
3,4-Benzpyren
3,4-Benzpyrene
3,4-Benzypyrene
6,7-Benzopyrene
B(a)P
BP
BaP
Benz(a)pyrene
Benzo(d,e,f)chrysene
Coal tar pitch volatiles: benzo(a)pyrene
RCRA waste number U022
|
| Type of Test |
Route of Exposure |
Species Observed |
Dose Data |
Reaction Severity |
Reference |
|
Standard Draize test
|
Administration onto the skin
|
Rodent - mouse
|
14 ug
|
Mild
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 4,333,1978
|
|
| Type of Test |
Route of Exposure |
Species Observed |
Dose Data |
Toxic Effects |
Reference |
|
LD50 - Lethal dose, 50 percent kill
|
Subcutaneous
|
Rodent - rat
|
50 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 69,103,1967
|
|
LDLo - Lowest published lethal dose
|
Intraperitoneal
|
Rodent - mouse
|
500 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 23,288,1972
|
|
LDLo - Lowest published lethal dose
|
Intrarenal
|
Amphibian - frog
|
9 mg/kg
|
Details of toxic effects not reported other than lethal dose value
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 24,1969,1964
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
100 mg/kg
|
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 39,541,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
40 mg/kg
|
Liver - change in gall bladder structure or function
Liver - other changes
Biochemical - Metabolism (Intermediary) - other
|
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1049,1968
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
100 mg/kg
|
Reproductive - Maternal Effects - ovaries, fallopian tubes
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,379,1991
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
80 mg/kg
|
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - ovaries, fallopian tubes
|
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 28,133,1979
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
100 mg/kg
|
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - ovaries, fallopian tubes
|
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 28,133,1979
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
80 mg/kg
|
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - ovaries, fallopian tubes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 53,249,1980
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Non-mammalian species
|
2 mg/kg
|
Immunological Including Allergic - decrease in humoral immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,174,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Non-mammalian species
|
3 mg/kg
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 192,45,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
50 mg/kg
|
Blood - changes in bone marrow (not otherwise specified)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 193,84,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
25 mg/kg
|
Brain and Coverings - other degenerative changes
Behavioral - changes in motor activity (specific assay)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 129,33,2002
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
266.7 ng/kg
|
Brain and Coverings - other degenerative changes
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 133,211,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
50 mg/kg
|
Liver - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
|
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 143-144,55,2003
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - rat
|
12 mg/kg
|
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 143,223,2003
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - rat
|
12 mg/kg
|
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 150,179,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
50 mg/kg
|
Lungs, Thorax, or Respiration - other changes
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 202,244,2005
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - rat
|
10.5 mg/kg
|
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
Biochemical - Metabolism (Intermediary) - other
|
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 24,249,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Non-mammalian species
|
2 mg/kg
|
Immunological Including Allergic - decrease in humoral immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,230,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
500 mg/kg
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Biochemical - Metabolism (Intermediary) - other
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,277,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
12.5 mg/kg
|
Brain and Coverings - other degenerative changes
Behavioral - changes in motor activity (specific assay)
Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,370,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
25 mg/kg
|
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of classical conditioning
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,379,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
25 mg/kg
|
Behavioral - alteration of operant conditioning
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,379,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
100 mg/kg
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 211,132,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
7570 ug/kg
|
Immunological Including Allergic - decrease in humoral immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,397,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
50 mg/kg
|
Blood - changes in bone marrow (not otherwise specified)
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 213,105,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
25 mg/kg
|
Brain and Coverings - other degenerative changes
Behavioral - changes in motor activity (specific assay)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 26,427,2006
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
125 mg/kg
|
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
|
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 24,149,2005
|
|
| OTHER MULTIPLE DOSE TOXICITY DATA |
| Type of Test |
Route of Exposure |
Species Observed |
Dose Data |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
9 gm/kg/90D (intermittent)
|
Kidney/Ureter/Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,323,1996
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
2250 mg/kg/5W (intermittent)
|
Blood - changes in spleen
Immunological Including Allergic - decreased immune response
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 148,126,1998
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
400 mg/kg/2W (intermittent)
|
Immunological Including Allergic - decrease in humoral immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,86,1983
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - mouse
|
180 mg/kg/12D (intermittent)
|
Immunological Including Allergic - uncharacterized
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 48,13,1999
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Non-mammalian species
|
171 mg/kg/30D (continuous)
|
Endocrine - androgenic
Endocrine - estrogenic
Related to Chronic Data - changes in ovarian weight
|
MAERE* Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978- Volume(issue)/page/year: 24,179,1988
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
75 ug/m3/10D (intermittent)
|
Endocrine - estrogenic
Endocrine - other changes
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 16,801,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1000 mg/kg/10D (intermittent)
|
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,132,2003
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
75 ug/m3/10D (intermittent)
|
Endocrine - changes in luteinizing hormone
Endocrine - androgenic
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,527,2003
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
2.5 mg/kg/5W (intermittent)
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 15,479,2001
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
75 ug/m3/6H/60D (intermittent)
|
Liver - other changes
Endocrine - androgenic
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,325,2003
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
100 ug/m3/4H/10D (intermittent)
|
Reproductive - Maternal Effects - ovaries, fallopian tubes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,338,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
200 mg/kg/15D (intermittent)
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - increase in cellular immune response
Immunological Including Allergic - increase in humoral immune response
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 199,261,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - species unspecified
|
87.5 mg/kg/7D (intermittent)
|
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,195,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
5040 mg/kg/12W (continuous)
|
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,116,2005
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
1120 mg/kg/16W (intermittent)
|
Kidney/Ureter/Bladder - changes primarily in glomeruli
Kidney/Ureter/Bladder - proteinuria
Kidney/Ureter/Bladder - other changes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,90,2004
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
8 mg/kg/5W (intermittent)
|
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - increase in humoral immune response
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 157,31,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
8.4 mg/kg/2W (intermittent)
|
Liver - other changes
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 44,179,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3750 mg/kg/30D (intermittent)
|
Blood - changes in bone marrow (not otherwise specified)
Immunological Including Allergic - decreased immune response
Related to Chronic Data - death
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,347,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
375 mg/kg/30D (intermittent)
|
Immunological Including Allergic - decreased immune response
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,347,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
3 mg/kg/3D (intermittent)
|
Related to Chronic Data - changes in uterine weight
|
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 46,454,2004
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
0.6 mg/kg/30D (intermittent)
|
Blood - other hemolysis with or without anemia
Blood - changes in other cell count (unspecified)
Blood - changes in erythrocyte (RBC) count
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,141,2001
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
600 mg/kg/30D (intermittent)
|
Endocrine - changes in spleen weight
Blood - changes in spleen
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,141,2001
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
25000 mg/m3/10D (intermittent)
|
Endocrine - other changes
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,273,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
50 mg/kg/5W (intermittent)
|
Kidney/Ureter/Bladder - other changes in urine composition
Kidney/Ureter/Bladder - other changes
Kidney/Ureter/Bladder - changes in kidney weight
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,310,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
80 mg/kg/8W (intermittent)
|
Kidney/Ureter/Bladder - changes primarily in glomeruli
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,312,2001
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
160 mg/kg/16W (intermittent)
|
Kidney/Ureter/Bladder - proteinuria
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,312,2001
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
0.05 mg/m3/4H/10D (intermittent)
|
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - ovaries, fallopian tubes
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,369,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
200 mg/kg/5D (intermittent)
|
Lungs, Thorax, or Respiration - other changes
Biochemical - Metabolism (Intermediary) - other proteins
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,382,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
156 mg/kg/4W (intermittent)
|
Immunological Including Allergic - decrease in cellular immune response
Immunological Including Allergic - increase in humoral immune response
Nutritional and Gross Metabolic - weight loss or decreased weight gain
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 211,107,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
52987 ug/kg/7D (intermittent)
|
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
Blood - changes in spleen
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,397,2004
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
3750 mg/kg/30D (intermittent)
|
Blood - changes in bone marrow (not otherwise specified)
Related to Chronic Data - death
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 90,371,2006
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
75 ug/m3/60D (intermittent)
|
Endocrine - changes in luteinizing hormone
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Related to Chronic Data - changes in testicular weight
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 90,429,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
50 mg/kg/5W (intermittent)
|
Kidney/Ureter/Bladder - renal function tests depressed
Kidney/Ureter/Bladder - changes in kidney weight
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 164,214,2006
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
20 mg/kg/2W (intermittent)
|
Kidney/Ureter/Bladder - proteinuria
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 164,214,2006
|
|
| Type of Test |
Route of Exposure |
Species Observed |
Dose Data |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
15 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Gastrointestinal - tumors
Musculoskeletal - tumors
|
EXPTAX Experimentelle Pathologie (1967-1980). (Jena, Ger. Dem. Rep.) V.1-18, 1967-80. For publisher information, see EXPADD. Volume(issue)/page/year: 18,288,1980
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
16 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
|
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 12,65,1958
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - rat
|
455 ug/kg/60D (intermittent)
|
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
|
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 29,159,1980
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rat
|
39 mg/kg/6D (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,506,1969
|
|
TDLo - Lowest published toxic dose
|
Intramuscular
|
Rodent - rat
|
2400 ug/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: DOE/EV/03140-5
|
|
TDLo - Lowest published toxic dose
|
Intracerebral
|
Rodent - rat
|
22 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Tumorigenic - tumors at site of application
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,1927,1969
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - rat
|
1200 ug/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
|
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 10,1285,1989
|
|
TDLo - Lowest published toxic dose
|
Implant
|
Rodent - rat
|
150 ug/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
|
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 72,733,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
700 mg/kg/75W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - leukemia
|
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(12),14,1980
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - mouse
|
200 ng/m3/6H/13W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(7),23,1982
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
120 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
|
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 71,677,1971
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
28500 ug/kg/19W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
|
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume(issue)/page/year: 9,297,1987
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
25 ng/kg/110W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
|
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 50,266,1980
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
10 mg/kg
|
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 4,74,1980
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
300 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
|
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 6,569,1980
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
300 mg/kg
|
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Reproductive - Specific Developmental Abnormalities - respiratory system
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 55,227,1990
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
9 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
|
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,309,1983
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
480 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
|
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 135,84,1970
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - mouse
|
10 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 1,225,1940
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - mouse
|
200 mg/kg/10W (intermittent)
|
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958- Volume(issue)/page/year: 22,269,1979
|
|
TDLo - Lowest published toxic dose
|
Implant
|
Rodent - mouse
|
200 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
|
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 39,761,1979
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - mouse
|
80 mg/kg/8D (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
|
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 88(11),592,1979
|
|
TDLo - Lowest published toxic dose
|
Rectal
|
Rodent - mouse
|
200 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Blood - leukemia
Gastrointestinal - colon tumors
|
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 37,77,1980
|
|
TDLo - Lowest published toxic dose
|
Parenteral
|
Mammal - dog
|
819 mg/kg/26W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
|
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 65,921,1980
|
|
TDLo - Lowest published toxic dose
|
Implant
|
Mammal - dog
|
651 mg/kg/21W (continuous)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - dyspnea
Tumorigenic - tumors at site of application
|
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 65,921,1980
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Primate - monkey
|
40 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
|
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 127,594,1968
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - rabbit
|
17 mg/kg/57W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
|
HSZPAZ Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.21- 1895/96- Volume(issue)/page/year: 236,79,1935
|
|
TDLo - Lowest published toxic dose
|
Intravenous
|
Rodent - rabbit
|
30 mg/kg
|
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Peripheral Nerve and Sensation - structural change in nerve or sheath
|
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 85,369,1978
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - rabbit
|
145 mg/kg/2Y (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
Blood - leukemia
|
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 71,197,1980
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - hamster
|
420 mg/kg/21W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
|
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 65,56,1962
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - hamster
|
9500 ug/m3/4H/96W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Lungs, Thorax, or Respiration - tumors
|
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 66,575,1981
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - hamster
|
4000 ug/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 32,360,1972
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - hamster
|
64 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 3,231,1977
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - hamster
|
120 mg/kg/17W (intermittent)
|
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 25,271,1985
|
|
TDLo - Lowest published toxic dose
|
Implant
|
Rodent - hamster
|
5 mg/kg/22W (continuous)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5202,1987
|
|
TDLo - Lowest published toxic dose
|
Implant
|
Amphibian - frog
|
45 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney/Ureter/Bladder - Kidney tumors
|
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 20,143,1964
|
|
TD - Toxic dose (other than lowest)
|
Implant
|
Rodent - rat
|
500 ug/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 20,97,1983
|
|
TD - Toxic dose (other than lowest)
|
Administration onto the skin
|
Rodent - mouse
|
12 mg/kg/20D (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
|
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 6,1483,1985
|
|
TD - Toxic dose (other than lowest)
|
Intratracheal
|
Rodent - rat
|
200 mg/kg/15W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
|
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,199,1974
|
|
TD - Toxic dose (other than lowest)
|
Administration onto the skin
|
Rodent - mouse
|
26 mg/kg/65W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
|
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 102,381,1981
|
|
TD - Toxic dose (other than lowest)
|
Rectal
|
Rodent - mouse
|
560 mg/kg/14W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 20,117,1983
|
|
TD - Toxic dose (other than lowest)
|
Subcutaneous
|
Rodent - mouse
|
8 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 12,657,1952
|
|
TD - Toxic dose (other than lowest)
|
Intratracheal
|
Rodent - hamster
|
360 mg/kg/36W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 32,28,1972
|
|
TD - Toxic dose (other than lowest)
|
Intramuscular
|
Rodent - rat
|
3150 ug/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
|
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 21,72,1980
|
|
TD - Toxic dose (other than lowest)
|
Administration onto the skin
|
Rodent - mouse
|
18 mg/kg/73W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
|
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 38,149,1981
|
|
TD - Toxic dose (other than lowest)
|
Subcutaneous
|
Rodent - mouse
|
12 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
|
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 62,309,1971
|
|
TDLo - Lowest published toxic dose
|
Intratracheal
|
Rodent - mouse
|
0.5 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 477,41,2001
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
480 mg/kg/32W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 163,1,2001
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
20 mg/kg/5D (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - other changes
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 159,113,2000
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
240 mg/kg/12D (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 21,179,2000
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
32.3 mg/kg/8D (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Liver - tumors
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 137,137,1999
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
38 ug/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 185,13,2002
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
200 mg/kg
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
|
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955- Volume(issue)/page/year: -,950,1992
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
1000 ug/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,86,2003
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
14 mg/kg/14W (intermittent)
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,86,2003
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
100 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988- Volume(issue)/page/year: 35,93,2002
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
320 mg/kg/4W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Gastrointestinal - tumors
|
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 144,183,2003
|
|
TDLo - Lowest published toxic dose
|
Administration onto the skin
|
Rodent - mouse
|
30 mg/kg/10D (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
|
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 21,17,1984
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
80 mg/kg/8W (intermittent)
|
Tumorigenic - carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - increased incidence of tumors in susceptible strains
|
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 91,1380,2004
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
100 mg/kg
|
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,186,2002
|
|
| Type of Test |
Route of Exposure |
Species Observed |
Dose Data |
Sex/Duration |
Toxic Effects |
Reference |
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
40 mg/kg
|
female 14 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
|
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 272,89,1972
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
2 gm/kg
|
female 28 day(s) pre-mating
1-22 day(s) after conception
|
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 20,224,1964
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - rat
|
1344 mg/kg
|
female 15 day(s) pre-mating - 5 day(s) post-birth
|
Reproductive - Effects on Newborn - live birth index (measured after birth)
|
DOESD6 DOE Symposium Series. (NTIS, 5285 Port Royal Rd., Springfield, VA 22161) No.45- 1978- Volume(issue)/page/year: 54,410,1981
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - rat
|
60 mg/kg
|
female 16-18 day(s) after conception
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970- Volume(issue)/page/year: 38,291,1980
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - rat
|
150 mg/kg
|
female 6-8 day(s) after conception
|
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
|
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 42,195,1986
|
|
TDLo - Lowest published toxic dose
|
Intramuscular
|
Rodent - rat
|
2100 ug/kg
|
female 15-19 day(s) after conception
|
Reproductive - Effects on Newborn - behavioral
|
JDPHDH Journal of Developmental Physiology. (Oxford University Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979- Volume(issue)/page/year: 19,67,1993
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
100 mg/kg
|
female 16 day(s) pre-mating - 5 day(s) post-birth
|
Reproductive - Maternal Effects - oogenesis
|
DOESD6 DOE Symposium Series. (NTIS, 5285 Port Royal Rd., Springfield, VA 22161) No.45- 1978- Volume(issue)/page/year: 54,410,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
1280 mg/kg
|
female 16 day(s) pre-mating - 5 day(s) post-birth
|
Reproductive - Effects on Newborn - germ cell effects (in offspring)
|
DOESD6 DOE Symposium Series. (NTIS, 5285 Port Royal Rd., Springfield, VA 22161) No.45- 1978- Volume(issue)/page/year: 54,410,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
100 mg/kg
|
female 7-16 day(s) after conception
|
Reproductive - Effects on Newborn - delayed effects
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 19,37A,1979
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
100 mg/kg
|
multigenerations
|
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
|
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 24,183,1981
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
75 mg/kg
|
female 12-14 day(s) after conception
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 32,29A,1985
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Rodent - mouse
|
100 mg/kg
|
female 7-16 day(s) after conception
|
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
|
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 24,183,1981
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
50 mg/kg
|
female 1 day(s) pre-mating
|
Reproductive - Maternal Effects - oogenesis
|
PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For publisher information, see DPTHDL. Volume(issue)/page/year: 1,143,1980
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
1500 mg/kg
|
male 5 day(s) pre-mating
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
|
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,712,1981
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
300 mg/kg
|
female 16-18 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system
|
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 6,569,1980
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
200 mg/kg
|
female 7 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
Reproductive - Specific Developmental Abnormalities - skin and skin appendages
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 20,365,1979
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
150 mg/kg
|
female 8 day(s) after conception
|
Reproductive - Effects on Newborn - stillbirth
|
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: CONF-771017
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - mouse
|
250 mg/kg
|
female 13-17 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system
|
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 42,259,1994
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
160 mg/kg
|
female 12 day(s) after conception
|
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - biochemical and metabolic
|
PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For publisher information, see DPTHDL. Volume(issue)/page/year: 1,85,1980
|
|
TDLo - Lowest published toxic dose
|
Subcutaneous
|
Rodent - mouse
|
12 gm/kg
|
multigenerations
|
Reproductive - Specific Developmental Abnormalities - respiratory system
|
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 55,227,1990
|
|
TDLo - Lowest published toxic dose
|
Unreported
|
Rodent - mouse
|
40 ug/kg
|
female 1 day(s) pre-mating
|
Reproductive - Maternal Effects - oogenesis
|
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 76,18,1984
|
|
TDLo - Lowest published toxic dose
|
Intraperitoneal
|
Rodent - hamster
|
10 mg/kg
|
male 5 day(s) pre-mating
|
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
|
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 8,929,1981
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
75 ug/m3
|
female 11-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 16,801,2002
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
25 ug/m3
|
female 11-20 day(s) after conception
|
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
|
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 16,801,2002
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
25 ug/m3
|
female 11-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - live birth index (measured after birth)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,125,2003
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
100 ug/m3
|
female 14-17 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,125,2003
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
100 ug/m3
|
female 8-21 day(s) after conception
|
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
Reproductive - Effects on Newborn - other neonatal measures or effects
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72(Suppl 1),338,2003
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - species unspecified
|
875 mg/kg
|
female 4-10 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,195,2005
|
|
TDLo - Lowest published toxic dose
|
Oral
|
Mammal - species unspecified
|
87.5 mg/kg
|
female 4-10 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetal death
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,195,2005
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
0.025 mg/m3
|
female 11-20 day(s) after conception
|
Reproductive - Specific Developmental Abnormalities - Central Nervous System
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,335,2002
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
100 ug/m3
|
female 14-17 day(s) after conception
|
Reproductive - Effects on Newborn - biochemical and metabolic
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,274,2001
|
|
TCLo - Lowest published toxic concentration
|
Inhalation
|
Rodent - rat
|
25 ug/m3
|
female 10-19 day(s) after conception
|
Reproductive - Effects on Embryo or Fetus - fetal death
|
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,369,2002
|
|
| Type of Test |
Route of Exposure |
Species Observed |
Dose Data |
Reference |
|
Mutation in microorganisms
|
|
Bacteria - Salmonella typhimurium
|
312 ng/plate
|
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 44,131,1984
|
|
Mutation test systems - not otherwise specified
|
|
Bacteria - Salmonella typhimurium
|
1 mg/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
|
|
DNA adduct
|
|
Bacteria - Salmonella typhimurium
|
147 gm/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 109,183,1983
|
|
Phage inhibition capacity
|
|
Bacteria - Salmonella typhimurium
|
3900 pmol/plate
|
PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 9,337,1979
|
|
Mutation in microorganisms
|
|
Bacteria - Escherichia coli
|
1 umol/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 60,395,1979
|
|
Mutation test systems - not otherwise specified
|
|
Bacteria - Escherichia coli
|
700 pmol/tube
|
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,5971,1982
|
|
Mutation in microorganisms
|
|
Bacteria - Escherichia coli
|
200 nmol/plate
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,87,1984
|
|
DNA repair
|
|
Bacteria - Escherichia coli
|
70 ug/well
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,53,1977
|
|
DNA damage
|
|
Bacteria - Escherichia coli
|
500 mg/L
|
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 103,275,1965
|
|
Phage inhibition capacity
|
|
Bacteria - Escherichia coli
|
400 ng/plate
|
CSHCAL Cold Spring Harbor Conferences on Cell Proliferation. (Cold Spring Harbor, NY) V.1-10, 1974-83. Volume(issue)/page/year: 4,1451,1977
|
|
Mutation in microorganisms
|
|
Bacteria - Bacillus subtilis
|
5 gm/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,19,1977
|
|
DNA damage
|
|
Bacteria - Bacillus subtilis
|
200 ug/disc
|
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,175,1981
|
|
DNA adduct
|
|
Microorganism - not otherwise specified
|
3 umol/L
|
PNCCA2 Proceedings, National Cancer Conference. (Philadelphia, PA) V.1-7, 1949-72. For publisher information, see CANCAR. Volume(issue)/page/year: 5,39,1965
|
|
Unscheduled DNA synthesis
|
|
Microorganism - not otherwise specified
|
1 mg/L
|
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 2,417,1981
|
|
DNA inhibition
|
|
Microorganism - not otherwise specified
|
200 ug/L
|
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 74,1378,1977
|
|
DNA inhibition
|
|
Microorganism - not otherwise specified
|
100 ug/L
|
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 74,1378,1977
|
|
DNA adduct
|
|
Microorganism - not otherwise specified
|
11 ng/L
|
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 39,205,1982
|
|
DNA damage
|
|
Microorganism - not otherwise specified
|
100 umol/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,235,1996
|
|
Specific locus test
|
Oral
|
Insect - Drosophila melanogaster
|
250 umol/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 234,71,1990
|
|
DNA repair
|
Oral
|
Insect - Drosophila melanogaster
|
100 mg/L
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 290,175,1993
|
|
DNA adduct
|
Oral
|
Insect - Drosophila melanogaster
|
1 mmol/L
|
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 23,171,1994
|
|
Sex chromosome loss and nondisjunction
|
Parenteral
|
Insect - Drosophila melanogaster
|
5 mmol/L
|
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,302,1973
|
|
Sex chromosome loss and nondisjunction
|
Oral
|
Insect - Drosophila melanogaster
|
100 umol/L
|
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year: 102,271,1983
|
|
Mutation in microorganisms
|
|
Yeast - Saccharomyces cerevisiae
|
1 gm/L
|
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,414,1981
|
|
Mutation in microorganisms
|
|
Yeast - Saccharomyces cerevisiae
|
50 mg/L
|
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 33,1576,1985
|
|
Gene conversion and mitotic recombination
|
|
Yeast - Saccharomyces cerevisiae
|
10 ug/plate
|
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,456,1981
|
|
Sex chromosome loss and nondisjunction
|
|
Yeast - Saccharomyces cerevisiae
|
150 mg/L
|
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,468,1981
|
|
Micronucleus test
|
Multiple routes
|
Non-mammalian species
|
1000 ppb
|
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 390,33,1997
|
|
Micronucleus test
|
Multiple routes
|
Non-mammalian species
|
10 ppb/8D (continuous)
|
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8,41,1986
|
|
Micronucleus test
|
Intraperitoneal
|
Fish - not otherwise specified
|
10 mg/kg
|
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 47,147,1986
|
|
Specific locus test
|
Oral
|
Insect - not otherwise specified
|
500 ppm | | |
